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. 2004 Jun 21;165(6):857–867. doi: 10.1083/jcb.200401133

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Copyright © 2004, The Rockefeller University Press

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Figure 6. — RNF-5 has a role in the maintenance of muscle dense bodies. (A–D) rnf-5(RNAi) analysis. (A and B) Control animals double stained with the anti-RNF-5 (A; green) and anti-DEB-1/vinculin (B; red) antibodies. (C and D) rnf-5(RNAi) animals. Note weak staining with the RNF-5 antibody in C, demonstrating that the RNAi treatment indeed depleted the endogenous RNF-5. Note the aberrant structure of dense bodies and muscle–muscle cell boundaries in (D). (E) Staining of the rnf-5(tm794) homozygous animals with anti-DEB-1/vinculin antibody. (F) Staining of unc-95(su33) adult muscle with anti-RNF-5 antibody. Note the aberrant dense body structure as compared with A. (G) RNF-5 (green) and DEB-1/vinculin (red) are localized in close proximity in the muscle dense bodies. (H) Partial colocalization (yellow) of RNF-5 (red) with GFP (green) of the UNC-95::GFP expression construct in muscle dense bodies. Arrowheads indicate the dense bodies. Arrows indicate muscle–muscle cell boundaries. Bars, 10 μm.