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. 2004 Oct 11;167(1):99–110. doi: 10.1083/jcb.200401085

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Copyright © 2004, The Rockefeller University Press

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Figure 8. — Recovery of anterograde transport of APP vesicles after coexpression of tau and MARK2. (a–c) RGC axon transfected with CFP-tau (a), YFP-MARK2 (b), and APP-mRFP (c). The time series in panel c shows recovery of anterograde movements. Open and closed arrowheads show two vesicles moving to the right at different speeds. (d) Histogram showing APP vesicle movements in control (left), after tau transfection (middle), after cotransfection of tau and MARK2 (right). In control cells almost all vesicles are mobile, and anterograde movements dominate. After tau transfection ∼40% of vesicles become immobile, and the net flow becomes retrograde. MARK2 partially relieves the inhibition by tau, the net flow becomes anterograde again.