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. 2004 Oct 25;167(2):269–279. doi: 10.1083/jcb.200403128

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Copyright © 2004, The Rockefeller University Press

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Figure 3. — The 4q telomere favors the heterochromatic compartment and, in particular, the nuclear periphery. This specific localization is striking when compared to other loci on chromosome 4 and to other telomeres. (A) The 4q35 (red, arrows) is found at either the nuclear periphery or next to the nucleolus as demarcated by fibrillarin (blue) in this fibroblast. (B) 4q35 (red, arrows) localizes within the peripheral rim (DAPI, blue) defined by depletion of hnRNA (green). (C) The peripheral localization of 4q (red) contrasts with the internal localization of 4p (green). Lamin A and nucleoli were detected simultaneously (blue). (D) The centromere of chromosome 4 (green) favors the nucleolus (blue), whereas the 4q telomere (red) is oriented at the periphery. (E) Analysis of three 4q subtelomeric probes reveals no preferred ordering between these three loci with respect to the periphery. RP11-279K24 (red) is more peripheral than RP11-597P9 (green) in one allele in contrast to the loci at the other allele. (F) Likewise, RP11-279K24 (red) is more peripheral than D4Z4 (green) in one allele in contrast to the other. (G) Chromosome 17q (red) and 17p (green) avoid the nuclear periphery and are often in the vicinity of the nucleolus (blue), particularly in myotubes. (H) The 17q (red) telomere frequently colocalizes with SC35 domains (blue) in a myoblast. (I) Quantitative distributions of total or specific telomeres (or centromere) in myoblasts. We analyzed 1,000 total telomeres, >800 4q, 200 4p, 200 4cen, 100 17p, and 100 17q signals.