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. 2004 Dec 20;167(6):1123–1135. doi: 10.1083/jcb.200405148

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Copyright © 2004, The Rockefeller University Press

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Figure 8. — Doxycycline-induced Pax4 stimulates β-cell proliferation in human islets. (A) Proliferation was measured by BrdU incorporation in dispersed islets expressing either Pax4 wt or R129W. Islets were cultured with or without 0.5 μg/ml of doxycycline in the presence of 10 μM BrdU. Immunocytochemical detection of BrdU incorporation (green) and nuclei staining (DAPI in blue) was performed 48 h later. (B) Forced expression of Pax4-induced proliferation in human islet β-cell replication as assessed by costaining of BrdU and insulin (arrows). Bars, 50 μM.