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. 2003 Jan 20;160(2):189–200. doi: 10.1083/jcb.200211046

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Copyright © 2003, The Rockefeller University Press

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Figure 4. — Dynamics of mitochondria in wild-type and mutant cells. Still frames from time-lapse confocal microscopy. (A) In a wild-type cell, two pairs of mitochondria can be seen moving toward each other. These pairs contact end-to-end and fuse immediately. Note that mitochondria move along their long axes. (B) In a Mfn1 mutant cell, the mitochondria move in an undirected manner. (C) In a Mfn2 mutant cell, two ovoid mitochondria contact each other but do not fuse until much later. Note also the lack of directed movement in most mitochondria. (D) One spherical Mfn2-deficient mitochondrion protrudes a tubular extension that separates and then migrates away along its long axis. Images were processed in Adobe Photoshop^® with the emboss filter, and selected mitochondria were manually highlighted in blue. See also videos 1–3 available at http://www.jcb.org/cgi/content/full/jcb.200211046/DC1.