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. 2003 Jan 20;160(2):189–200. doi: 10.1083/jcb.200211046

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Copyright © 2003, The Rockefeller University Press

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Figure 7. — Rescue of Mfn1-deficient cells Mfn1 mutant cells. Mfn1 mutant cells (A) were infected with a retrovirus expressing Myc epitope-tagged versions of Mfn1 (B), Mfn1(K88T) (C), Mfn2 (D), or dominant- negative Drp1(K38A) (E). In the merged images, mitochondrial morphology is revealed by MitoTracker Red staining, and infected cells are identified by immunofluorescence with an anti-Myc antibody (green). In E, the signals are largely nonoverlapping because most of the Drp1 resides in a cytosolic pool. The results are summarized in F, which depicts the percentage of infected cells belonging to each of four morphological classifications. 600 cells were scored for each infection.