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. 2003 Aug 4;162(3):377–382. doi: 10.1083/jcb.200301088

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Copyright © 2003, The Rockefeller University Press

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Figure 4. — Updated models for the kinetochore–microtubule interface that include contributions from flux. Drawings in A–C are modified from Rieder and Salmon (1998). OP is a cross section of one microtubule attachment site in the outer plate of the kinetochore, and IP is a cross section of the inner plate. The stretch of the centromere beyond its rest length indicates the tension generated. Microtubule attachment and resistance to translocation through the attachment site may be provided by the microtubule motors CENP-E and cytoplasmic dynein, the nonmotor microtubule–binding domain of CENP-E, the microtubule binding domain of the p150 component of the dynactin complex bound to dynein, and unknown microtubule-binding proteins within the attachment site (see text for details).