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Gross appearance of rescued PTHrP-knockout mice. (A) Relative size of a rescued-knockout mouse at 8 weeks of age (below) as compared with a wild-type littermate (above). Foreshortening of the limbs is apparent by this age. The cranial chondrodystrophy in the rescued-knockout mouse (C), as compared with a normal animal (B), includes doming of the calvarium, frontal bossing, and a flattened snout.
