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Comparison of skulls from adult wild-type mice (A and B) and rescued PTHrP-knockouts (C and D). External incisors and molars are clearly absent from both the maxilla (compare A and C) and mandible (compare B and D) in these animals. The lack of functional dentition in the rescued-knockout is superimposed on the underlying features of the cranial chondrodystrophy, which includes foreshortening of the maxilla and mandible.
