Figure 7.

Dental phenotype of doubly rescued PTHrP-knockout mice. (A) Immunohistochemical staining for K14 (dark gray) in a sagittal section from a normal neonatal incisor localizes to the reduced enamel epithelium (re) on the labial surface. (B) Eruption of both incisors and molars (enlarged in Insets) is readily apparent in the maxilla and mandible of an adult doubly rescued animal. (C) A sagittal radiograph of an adult doubly-rescued PTHrP-knockout mouse clearly reveals the malocclusion of the incisors in the rescued-knockout caused by the underlying chondrodystrophy. Note the restoration of root extension in the lower incisor (arrowhead). (Bar = 27 μm.)