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. 2003 Apr 14;161(1):131–142. doi: 10.1083/jcb.200211002

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Copyright © 2003, The Rockefeller University Press

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Figure 6. — Effects of PIX mutants on spine morphology and synaptic density. (A) Hippocampal neurons were transfected with various PIX constructs at day 7 in culture and imaged at day 14 in culture. Note the increase in dendritic protrusions in PIX- and PIXΔGBD- overexpressing neurons and the decrease in spines and dendritic protrusions in PIX-LL–expressing neurons. “Control” denotes GFP-expressing neurons. Bar, 5 μm. (B) Quantification of the number of spines and dendritic protrusions in various PIX constructs. (C) Quantification of the number of synapses in various PIX constructs. The difference between PIX constructs and the untransfected neurons (control) was statistically significant as determined by the Student's t test (*P < 0.0001).