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. 1998 Sep 29;95(20):11852–11857. doi: 10.1073/pnas.95.20.11852

Figure 3.

Figure 3

Response of ob/ob TG mice to leptin treatment. Leptin (400 ng/ml) or PBS was delivered to groups of five ob/ob TG mice as a 28-day s.c. infusion by using Alzet osmotuic pumps. (A) The food intake and body weights of mice were measured daily. Data are shown as mean ± SD. Leptin treatment resulted in a marked decrease in food intake and body weight. (B) Leptin treatment of the ob/ob TG mice resulted in a decrease in body fat content from 30% to 3%. The treatment did not affect lean body mass or the amount of body water.