Table 1.
Phenotypic features of the ob/ob, ob/ob TG, ob/+, and ob/+ TG mice
| Males
|
Females
|
|||||||
|---|---|---|---|---|---|---|---|---|
| ob/+ TG | ob/+ None | ob/ob TG | ob/ob None | ob/+ TG | ob/+ None | ob/ob TG | ob/ob None | |
| Plasma mouse leptin (ng/ml) | 2.80 | 3.49 | 0 | 0 | 3.60 | 4.04 | 0 | 0 |
| (±0.96) | (±1.89) | (±0) | (±0) | (±0.39) | (±2.65) | (±0) | (±0) | |
| Plasma human leptin (ng/ml) | 1.54 | 0 | 1.68 | 0 | 2.19 | 0 | 1.90 | 0 |
| (±0.42) | (±0) | (±0.48) | (±0) | (±0.34) | (±0) | (±0.60) | (±0) | |
| Blood glucose (mg/dl) | 162.9 | 171.8 | 144.8 | 265.2 | 134.7 | 147.3 | 150.9 | 228.4 |
| (±23.7) | (±14.2) | (±19.3) | (±74.9) | (±10.4) | (±20.1) | (±14.3) | (±51) | |
| Plasma insulin (ng/ml) | 0.70 | 1.49 | 2.42 | 28.62 | 0.52 | 0.61 | 1.60 | 7.55 |
| (±0.36) | (±0.90) | (±1.08) | (±14.19) | (±0.11) | (±0.17) | (±0.77) | (±7.27) | |
| Plasma corticosterone (ng/ml) | 132.3 | 94.6 | 85.7 | 248.1 | 107.3 | 122.9 | 152.2 | 210.3 |
| (±81.9) | (±41.7) | (±36.7) | (±58.0) | (±48.2) | (±57.8) | (±41.4) | (±45.8) | |
| Plasma thyroxine (μg/dl) | 3.52 | 3.23 | 4.00 | 3.35 | 3.67 | 3.88 | 4.97 | 3.54 |
| (±1.25) | (±0.85) | (±1.00) | (±0.53) | (±1.64) | (±0.58) | (±0.83) | (±0.44) | |
| Fertility (%) | 6/6 | 3/3 | 6/6 | 0/5 | 6/6 | 10/10 | 10/12 | 0/5 |
| (100%) | (100%) | (100%) | (0%) | (100%) | (100%) | (83%) | (0%) | |
| Litter size | 5.7 (±2.7) | 7.3 (±2.7) | 5.0 (±1.3) | 0 | ||||
| n | 11 | 9 | 6 | 0 | ||||
Data are mean (± SD); n = 5–11 per group for mouse leptin; n = 5–14 for human leptin; n = 5–13 for glucose and insulin; n = 7–13 for corticosterone; n = 6–11 for thyroxine.