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. 2003 Apr 28;161(2):281–294. doi: 10.1083/jcb.200208092

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Copyright © 2003, The Rockefeller University Press

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Figure 6. — Monoorientation is not corrected in Hesperadin-treated PtK1 cells before anaphase. Live cell imaging of a PtK1 cell treated with 500 nM Hesperadin. Selected stills of a time-lapse movie (Video 2, available at http://www.jcb.org/cgi/content/full/jcb.200208092/DC1), elapsed time from NEB in h:min is shown in the upper left. The approximate positions of the spindle poles are marked by yellow stars. Red dots indicate the centromeric region of two different chromosomes. After NEB (0:00), some chromosomes align to the metaphase plate, but the majority of chromosomes are monooriented (0:17–0:44). Monooriented chromosomes move on the spindle (compare distance between red dots and yellow stars), but they fail to congress. Upon the onset of anaphase, sister chromatids of bioriented chromosomes are pulled to opposite poles (example marked by red arrowheads), whereas both sisters of the monooriented chromosomes move to the same pole.