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. 2003 Apr 28;161(2):229–236. doi: 10.1083/jcb.200207117

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Copyright © 2003, The Rockefeller University Press

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Figure 1. — csc-1 encodes a 27-kD protein required for chromosome segregation and cytokinesis. (A) csc-1 mutants have defects in chromosome segregation and cytokinesis. Images shown are selected from a time-lapse Nomarski recording of a wild type and an embryo derived from a homozygous csc-1(t1171) mutant hermaphrodite. (B) Schematic depicting the position of the csc-1 locus. SNP mapping placed csc-1 between SNP L and SNP R. (C) csc-1(RNAi) and icp-1(RNAi) cause similar chromosome segregation phenotypes. Embryos dissected from worms expressing GFP–histone H2B and depleted of CSC-1 or ICP-1 by RNAi were imaged by Nomarski and fluorescence optics. Time shown is relative to nuclear envelope breakdown. The GFP signal is shown as a red overlay. (D) The sequence of the CSC-1 protein; the potential coiled-coil region is underlined and the imperfect repeat is double underlined. Glutamine 128, the residue mutated in csc-1(t1171), is indicated by an asterisk.