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. 2002 Jul 8;158(1):31–37. doi: 10.1083/jcb.200203022

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Copyright © 2002, The Rockefeller University Press

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Figure 3. — MTs perpendicular to the leading edge move at the same rate as the f-actin in the lamellum, but not in the lamellipodium. (a) Single image from the time-lapse series in Video 4 (available at http://www.jcb.org/cgi/content/full/jcb.200203022/DC1) shows an MT (green) oriented perpendicular to the leading edge within the lamellum. (c) Kymograph of the boxed region in (a). Speckles along the MT appear as parallel green streaks in the kymograph as the MT moves retrograde at the exact same rate as the immediately adjacent f-actin speckles (red streaks). (b) Single image from the time-lapse series seen in Video 5 (available at http://www.jcb.org/cgi/content/full/jcb.200203022/DC1) of a perpendicular MT in the lamellipodium. (d) Kymograph of the boxed region in (b). The slope of the green MT streaks in the lamellipodium (lp, green line) are much shallower than the slopes of the red f-actin streaks (red line), indicating f-actin moves faster than the MT at the lamellipodium. In the lamellum (la), the slopes of the red and green streaks match (yellow line), indicating coordinated movement of the MT and f-actin at this region. Bar, 3 μm.