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. 2002 Oct 28;159(2):361–372. doi: 10.1083/jcb.200207050

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Copyright © 2002, The Rockefeller University Press

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Figure 6. — Claudin-1 is located at the paranodal loops and along the mesaxon. Double immunofluorescence labeling of teased mouse sciatic nerve fibers using antibodies to claudin-1 (green) and Na⁺ channels (A–C, NaCh), PATJ (D–F), or Caspr (G–I), all in red. The right panel of each row shows the merged image. Claudin-1 was found in the paranodal region at both sides of the node (A–C), and colocalized with PATJ (D–F). Note that claudin-1 and Caspr are localized in distinct parts of the paranode (G–I). The inset in panel C shows internodal staining of claudin-1; this was more pronounced in smaller axons. Bar, 15 μm.