Table I. Localization of tight junction proteins at Schmidt-Lanterman incisures and paranodal loops in myelinating Schwann cells.
| Proteins | Schmidt-Lanterman incisures | Paranodal loops | Antibody source/reference |
|---|---|---|---|
| Transmembrane | |||
| JAM | − | − | Bazzoni et al. (2000) |
| Occludin | − | − | Nagaoka et al. (1999) |
| Claudin-1 | − | +++ | Zymed |
| Claudin-2 | + | − | Zymed |
| Claudin-5 | +++ | − | Zymed and Morita et al. (1999c) |
| Claudin-11 | − | − | Morita et al. (1999b) |
| MUPP1 | +++ | − | Material and methods |
| Peripheral cytoplasmic | |||
| PATJ | + | +++ | Material and methods |
| ZO-1 | +++ | +++ | Zymed |
| ZO-2 | +++ | +++ | Bruce Stevenson |
| AF-6 | − | − | Transduction Laboratories |
| Par-3 | +++ | +++ | Lin et al. (2000) |
| Pals-1 | − | − | Kamberov et al. (2000) |
| MAGI-1 | − | − | Sigma-Aldrich |
| S-SCAM/MAGI-2 | +++ | − | Unpublished data; Sigma-Aldrich |
| Slipr/MAGI-3 | − | − | Unpublished data; Sigma-Aldrich |
| Cingulin | − | − | Citi et al. (1988) |
Except for cingulin, all peripheral proteins contain PDZ domains. Out of three transmembrane proteins of TJ that bind PDZ domains (JAM, occludin, and claudin), only members of the claudin family are found in myelinating Schwann cells.