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. 2002 Oct 28;159(2):349–360. doi: 10.1083/jcb.200207060

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Copyright © 2002, The Rockefeller University Press

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Figure 8. — Position of all significantly reactive cysteines in Cx32. Solid filled circles in M2 and M3 indicate sites where channel block by MBB was highly significant (P < 0.01), whereas boldly circled residues with lighter shading (V84 and L89 in M2; F141 and Y151 in M3) showed conductance changes that were slightly less significant (0.01 < P < 0.05). Lightly shaded residues in M1 (I33) and M4 (A196 and S198) showed block in response to extracellular MBB application, and are not thought to line the pore. Boldly circled open sites indicate reactive positions where cysteine substitution induced reversed gating. Reactivity of these residues suggests that they are accessible in the closed state, but not necessarily in the native, open conformation.