Table 1.
Methylcellulose cultures
| Colonies | Neutrophils, % | Neutrophils, × 104/ml | |
|---|---|---|---|
| G-CSFa | |||
| Control | ND | 36 ± 9.0 | 8.0 ± 6.4 |
| Tg259 | ND | 17 ± 1.5, P = 0.07 | 5.2 ± 1.4, P = 0.48 |
| Tg237 | ND | 6 ± 2.0, P = 0.03 | 1.5 ± 0.5, P = 0.19 |
| G-CSFb | |||
| Control | 32.7 ± 8.0 | 39.5 ± 6.1 | 0.8 ± 0.1 |
| Tg259 | 45.7 ± 2.1, P = 0.10 | 25.5 ± 0.5, P = 0.06 | 0.5 ± 0.1, P = 0.05 |
| Tg237 | 44.3 ± 7.0, P = 0.13 | 6.3 ± 1.7, P = 0.008 | 0.1 ± 0.04, P = 0.008 |
| GM-CSFb | |||
| Control | 87 ± 8.9 | 37.7 ± 5.1 | 9.0 ± 0.9 |
| Tg259 | 119 ± 11.6, P = 0.02 | 21.3 ± 5.0, P = 0.02 | 5.0 ± 0.8, P = 0.005 |
| Tg237 | 114 ± 19.7, P = 0.13 | 9.8 ± 2.0, P = 0.005 | 2.2 ± 0.8, P = 0.0006 |
Data were derived from independent experiments a and b. Data were derived from results with three mice in each group in each experiment. P values, transgenic mice compared to control mice. ND, not determined.
a
Cells were plated at 2.5 × 105/ml.
b
Cells were plated at 5.0 × 104/ml.