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. 2002 Jul 22;158(2):283–292. doi: 10.1083/jcb.200112025

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Copyright © 2002, The Rockefeller University Press

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Figure 4. — Powerful basal uncaging can trigger a regenerative CICR wave that is initiated in the granular region. Traces represent normalized fluorescence levels of fluo-4 from regions of interest shown in accompanying transmitted image. (A) The experiment is representative of those consisting of basally localized uncaging (orange region in transmitted image) followed by a cellular CICR transient. B shows an expanded section of upper trace including uncaging spike and initial phase of CICR transient. Lower panel of B shows pseudocolor confocal fluorescence images taken from time points indicated by arrows in the expanded trace. Uncaging produces a localized spike (dark blue trace and image 2) but Ca²⁺ also spills out of this region and throughout the cell, as shown by the slower and smaller rise in the granular part (red trace and image 3). The regenerative CICR transient is then initiated in this region, as indicated by the early rise of the granular (red) trace and images 4, 5, 6, and 7. F_pp ratio = 1.35.