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. 2002 Jul 22;158(2):283–292. doi: 10.1083/jcb.200112025

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Copyright © 2002, The Rockefeller University Press

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Figure 7. — Subthreshold concentrations of agonist potentiate CICR triggered by apical uncaging. Trace shows normalized fluorescence from regions shown in transmitted image. Top trace shows full time course of experiment in which localized apical uncaging (orange circle in fluorescence image) is performed in the absence and then presence of subthreshold CCK (1 pM). Area denoted by dashed box is expanded below. In this case, multiple uncaging events fail to trigger any CICR response in the absence of any other stimulation, but single, smaller uncaging spike initiates CICR when subthreshold agonist is present. F_pp ratio = 0.84.