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. 2002 Jul 22;158(2):283–292. doi: 10.1083/jcb.200112025

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Copyright © 2002, The Rockefeller University Press

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Figure 8. — Basally localized uncaging cannot initiate CICR in the basal region even in the presence of subthreshold agonist. Trace shows normalized fluo-4 fluorescence from regions shown in accompanying transmitted image. Cells were stimulated with 1 pM CCK throughout. Basally localized uncaging (area shown by orange circle in fluorescence image) of increasing magnitude produces uncaging spikes of increasing size. None of these spikes can trigger CICR until, finally, an uncaging event of large size results in spill-out of calcium into the apical region. This calcium then triggers a CICR wave that propagates in an apical-to-basal direction. This is shown by the early rise of the apical (red) trace. F_pp ratio = 1.9.