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. 2002 Jul 22;158(2):283–292. doi: 10.1083/jcb.200112025

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Copyright © 2002, The Rockefeller University Press

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Figure 9. — Uncaging-induced CICR can initiate oscillations in the presence of subthreshold stimulation. Trace shows normalized fluo-4 fluorescence from regions shown in accompanying transmitted image. Cells are perfused with a low concentration of agonist (10 pM CCK) for ∼8 min to establish that this dose is subthreshold. Then, apical-localized uncaging (area shown by dashed orange circle in fluorescence image) triggers a CICR wave (this section of the time course is expanded in dashed box above). After this CICR wave, and without further uncaging, the cell produces oscillations in calcium until the agonist is removed. F_pp ratio = 1.34.