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. 2002 Sep 16;158(6):1079–1087. doi: 10.1083/jcb.200202049

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Copyright © 2002, The Rockefeller University Press

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Figure 2. — Localization of endogenous β-catenin in melanoma cells and corresponding TCF/LEF transcriptional activity. (A) Melanoma cells (mouse B16 melanoma, human A375, human 501mel, and human SK-MEL-5) were assayed by immunofluorescence for the localization of β-catenin. As shown, B16 and A375 do not display aberrant nuclear accumulation of β-catenin in comparison with 501mel and SK-MEL-5, which display both cytoplasmic and nuclear β-catenin. (B) Bar graphs of the relative activity of TK-TOP, with optimal TCF/LEF binding sites and TK-FOP which carries mutated sites for TCF/LEF as an enhancer for the TK immediate early promoter driving luciferase.