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. 2002 Sep 16;158(6):1079–1087. doi: 10.1083/jcb.200202049

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Copyright © 2002, The Rockefeller University Press

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Figure 4. — β-catenin is associated with the endogenous MITF promoter and modulates MITF expression levels. (A) In vivo association of β-catenin with the mouse MITF promoter by chromatin immunoprecipitation. The mouse tyrosinase promoter is a transcriptionally active negative control. (B) Ectopic expression of β-catenin leads to endogenous upregulation of MITF protein levels, and conversely, dnTCF downregulates MITF protein as quantitated by flow cytometry and analysis of transfected (gated GFP-positive) cells.