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. 2002 Sep 30;158(7):1251–1262. doi: 10.1083/jcb.200204010

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Copyright © 2002, The Rockefeller University Press

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Figure 7. — The effect of trans-Golgi network collapse on normalized sodium current amplitude of control and HSV-1–infected DRG neurons. (a) Sodium currents of DRG neurons either treated with brefeldin A and/or infected with wt HSV-1. (b) Mean-normalized sodium current amplitude ± SEM for HSV-1–infected and uninfected DRG neurons with or without brefeldin A. Treatment with brefeldin A did not significantly alter the amplitude of sodium currents in infected or uninfected neurons. The normalized amplitudes of brefeldin A–treated HSV-1 infected and HSV-1–infected DRG neurons were both significantly smaller than the amplitudes of brefeldin A–treated or untreated control DRG neurons (Kruskal-Wallis test followed by the Kolmogorov-Smirnov pairwise comparison; P < 0.001). 70% of wt HSV-1–infected DRG neurons had no sodium current, whereas 71% of cells infected with wt HSV-1 and treated with brefeldin A had no sodium current.