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. 2003 Mar 3;160(5):753–767. doi: 10.1083/jcb.200212114

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Copyright © 2003, The Rockefeller University Press

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Figure 2. — Chemotaxis motility and serum-stimulated redistribution of v-Src to lamellipodia in FAK-containing cells. (A) ILK indirect IF of cells plated on FN in the presence of serum shows reduced numbers of focal contacts in FAK^−/− v-Src and DA2 v-Src cells. Indirect v-Src IF shows that FAK promotes v-Src association with focal contacts and membrane ruffles. Bar, 20 μm. (B) v-Src enhances the wound closure activity of FAK^−/− cells. Cell migration was assessed by 1-mm grid comparisons of four image sets; representative images are shown. (C) Serum-stimulated chemotaxis assays show that v-Src–transformed FAK^−/−, DA2, and FAK^+/+ cells exhibit similar properties of reduced migration compared with DA2 cells. Random motility was assessed in the presence of BSA. Values are means ± SD of triplicates from two independent experiments.