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. 1998 Sep 29;95(20):11880–11885. doi: 10.1073/pnas.95.20.11880

Figure 2.

Figure 2

Dichotomous effect of CC-chemokines on the replication of M-tropic vs. T-tropic HIV-1 strains in CD8-depleted PBMC from HIV seronegative donors infected in vitro. CD8-depleted PBMC from an HIV-uninfected donor were infected with various dilutions of either (A) an M-tropic HIV strain, JR-fl, or (B) a T-tropic primary isolate, SG, without (■) or with the addition of either RANTES (▩) or MCP-1 (▨) (100 ng/ml). Data are representative of three independent experiments. (C) One or more CC-chemokines (100 ng/ml) enhance the replication of a T-tropic HIV-1 strain (MN) in CD8-depleted PBMC or CD4+ T cells from nine different HIV seronegative donors (A–I). The CXC chemokine IL-8 was tested in CD8-depleted PBMC cultures from four different HIV seronegative donors. Data are represented as fold increase in peak viral replication (RT activity) in chemokine treated as compared with untreated cultures.