Table II. TFF1 treatment and constitutive and induced TFF1 expression induce increased levels of cdk inhibitors.
| Ckis | TFF1 treatment | Constitutive | Inducible | ||||||
|---|---|---|---|---|---|---|---|---|---|
| − | + | P | − | + | P | − | + | P | |
| INK4 | |||||||||
| P15 | 2 ± 0.8 | 5 ± 0.2 | <0.01 | 15 ± 4.1 | 37 ± 3.5 | <0.01 | 17 ± 0.4 | 18 ± 0.5 | NS |
| P16 | 44 ± 6.1 | 61 ± 2.3 | <0.05 | 50 ± 2.5 | 64 ± 1.8 | <0.05 | 37 ± 2 | 46 ± 1.5 | <0.05 |
| CIP | |||||||||
| P21 | 3 ± 1 | 7 ± 1.1 | <0.05 | 14 ± 3.5 | 20 ± 4.5 | NS | 11 ± 0.5 | 19 ± 1.5 | <0.05 |
| P27 | 13 ± 1.3 | 18 ± 0.8 | <0.05 | 3 ± 0.2 | 5 ± 1.5 | <0.05 | 3 ± 1 | 8 ± 1.5 | <0.05 |