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. 2002 Mar 18;156(6):1099–1111. doi: 10.1083/jcb.200110122

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Copyright © 2002, The Rockefeller University Press

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Figure 9. — Stratum corneum in claudin-1–deficient mice. (A) Ultrathin section electron microscopic images of ruthenium tetroxide-stained stratum corneum of the skin. Both in the Cln1 ⁺ ^/ ⁺ and Cln1 ⁻ ^/ ⁻ epidermis, well-organized lipid lamellae and lamellar bodies were clearly observed between flattened cornified cells (CC; top) and between cornified cells and granular cells (GC; bottom), respectively. Bars, 0.1 μm. (B) Isolated cornified CEs. There was no clear difference in appearance between the Cln1 ⁺ ^/ ⁺, Cln1 ⁺ ^/ ⁻, and Cln1 ⁻ ^/ ⁻ skin. Bar, 40 μm. (C) Expression levels of major components of cornified CEs, loricrin and involucrin, detected by immunoblotting. Whole cell lysates of the Cln1 ⁺ ^/ ⁺, Cln1 ⁺ ^/ ⁻, and Cln1 ⁻ ^/ ⁻ skin were examined using specific antibodies. (D) Expression levels of Klf4, transglutaminase-1 (TG1), and GAPDH (control) detected by Northern blotting.