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. 2002 Oct 14;159(1):91–102. doi: 10.1083/jcb.200202114

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Copyright © 2002, The Rockefeller University Press

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Figure 3. — Neutrophils respond in a hierarchal manner to competing gradients of chemoattractants. (a) Migration of neutrophils in competing chemotactic gradients. Six gradients were tested: the first consisted of optimal fMLP (1.0 pmol) and 1/100th optimal IL-8 (0.1 pmol), the second consisted of 1/100th optimal fMLP (0.01 pmol) and optimal IL-8 (10.0 pmol), and the third consisted of optimal gradients of fMLP and IL-8. The fourth gradient consisted of optimal IL-8 and optimal C5a (10.0 pmol). The fifth gradient consisted of optimal LTB₄ (10.0 pmol) and optimal fMLP. The final gradient consisted of optimal LTB₄ and optimal C5a. (b) Migration of p38 MAPK inhibited neutrophils from a well containing 10.0 pmol IL-8 or 1.0 pmol fMLP to wells containing various concentrations of fMLP or IL-8. Results are shown as mean ± SE (n = 10). *P < 0.05 compared with migration toward fMLP.

Figure 3. — Neutrophils respond in a hierarchal manner to competing gradients of chemoattractants. (a) Migration of neutrophils in competing chemotactic gradients. Six gradients were tested: the first consisted of optimal fMLP (1.0 pmol) and 1/100th optimal IL-8 (0.1 pmol), the second consisted of 1/100th optimal fMLP (0.01 pmol) and optimal IL-8 (10.0 pmol), and the third consisted of optimal gradients of fMLP and IL-8. The fourth gradient consisted of optimal IL-8 and optimal C5a (10.0 pmol). The fifth gradient consisted of optimal LTB₄ (10.0 pmol) and optimal fMLP. The final gradient consisted of optimal LTB₄ and optimal C5a. (b) Migration of p38 MAPK inhibited neutrophils from a well containing 10.0 pmol IL-8 or 1.0 pmol fMLP to wells containing various concentrations of fMLP or IL-8. Results are shown as mean ± SE (n = 10). *P < 0.05 compared with migration toward fMLP.