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. 2002 Oct 14;159(1):157–167. doi: 10.1083/jcb.200203115

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Copyright © 2002, The Rockefeller University Press

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Figure 1. — GDNF-induced survival of CG neurons is strictly dependent on the presence of TGFβ. CG neurons were seeded onto PORN/laminine-coated microtiter plates at a density of 3,000 cells per well. (A) Cells were treated with 10 ng/ml GDNF or 2 ng/ml TGFβ3 or both factors. As a control the neurons were left untreated or CNTF (10 ng/ml) was added. (B) Cells were treated with combinations of the indicated concentrations of GDNF (0.5 ng/ml to 10 ng/ml) and TGFβ (0.125 ng/ml to 2 ng/ml). The cultures were fixed after 24 h and the numbers of surviving neurons were counted. Each bar represents the mean and standard deviation of at least three independent experiments with every condition tested in triplicate per assay (***, P ≤ 0.01, **, P ≤ 0.05; determined in a Student's t test).