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. 2003 Oct 27;163(2):295–302. doi: 10.1083/jcb.200306148

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Copyright © 2003, The Rockefeller University Press

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Figure 3. — Cerebellar LTD is impaired in acute cerebellar slices of cGKI^pko mice. (A) LTD at parallel fiber–PC synapses of control mice (filled squares, n = 11 experiments) and cGKI^pko mice (open squares, n = 15 experiments). The black bar indicates the time of pairing. (B) Representative EPSCs recorded 5 min before and 20 min after LTD induction in a control mouse (ctr) and in a cGKI^pko mouse (pko). Traces are averages of 10 consecutive EPSCs. (C) Averages of all 120 combined climbing/parallel fiber responses recorded during the pairing procedure in two representative experiments obtained in PCs of a control mouse (ctr) and a cGKI^pko mouse (pko). The arrowheads indicate the time of concomitant parallel fiber and climbing fiber stimulation.