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. 2003 Oct 27;163(2):203–208. doi: 10.1083/jcb.200309175

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Copyright © 2003, The Rockefeller University Press

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Figure 1. — The endocytic adaptor interaction web. A schematic representation of the protein–protein interactions possible between clathrin, AP-2, and alternate endocytic adaptors. The sorting signal or putative cargo types recognized by the different adaptors are boxed in black. PtdIns(4,5)P₂-binding sites are indicated by the spherical gray attachments. AP-2 is modeled on the known molecular architecture of the core and appendages, but the different proteins are not to scale. pGPCR, phosphorylated G protein–coupled receptor; AMPA-R, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.