Table I. Measurements of proliferation and apoptosis in mutant and control nerves.
BrdU incorporating nuclei | TUNEL-positive cells | |||
---|---|---|---|---|
Age | mt | wt | mt | wt |
% | % | % | % | |
E15.5 | 24.6 ± 3.4(10) | 23.7 ± 3.0 (11) | 1.95 ± 0.67 (32) | 1.96 ± 0.75 (12) |
E17.5 | 35.5 ± 2.5(6) | 28.3 ± 3.6 (7) | 0.21 ± 0.17 (24) | 0.18 ± 0.10 (23) |
P5 | 0.74 ± 0.18 (14) | 0.54 ± 0.12 (11) |
Percentages (mean ± SEM) of nuclei incorporating BrdU and of TUNEL-positive cells in nerves of mutant (mt) and control (wt) mice. Number of experiments is in parentheses. By a paired, two-tailed t test, the percentages in mutant and control animals were not significantly different.