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Immunohistochemistry to detect p16 protein in human lung lesions. (A) Immunohistochemical detection of p16 protein (brown nuclear staining) in an area of bronchiolar squamous metaplasia. (B) Lack of detectable p16 protein in an area of bronchiolar squamous metaplasia with marked atypia. (C) Strong nuclear p16 immunostaining in a SCC. (D) Lack of p16 protein in a SCC.
