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. 2003 Nov 10;163(3):489–502. doi: 10.1083/jcb.200303017

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Copyright © 2003, The Rockefeller University Press

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Figure 5. — Cytoplasmic region of proHB-EGF is required for PLZF export after TPA stimulation. (A) Structures of cytoplasmic deletion mutants of proHB-EGF. These mutants, HBΔC10, HBΔC19, and HBΔC22, were truncated by 10, 19, and 22 amino acids, respectively, from the carboxy terminus of proHB-EGF. (B and C) Subcellular localization of CFP-PLZF in HT1080 cells stably expressing proHB-EGF and its cytoplasmic deletion mutants. CFP-PLZF was predominantly localized in the nucleus in these stable transfectants. In HT1080/HB-EGF and HT1080/HBΔC10 cells, TPA treatment distributed CFP-PLZF to the entire cytoplasm. However, in HT1080/HBΔC19 and HT1080/HBΔC22 cells, the export of CFP-PLZF from nucleus was not observed after TPA stimulation. Bar, 10 μm.