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. 2003 Nov 10;163(3):525–534. doi: 10.1083/jcb.200307111

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Copyright © 2003, The Rockefeller University Press

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Figure 2. — The p120-associated destruction mechanism is common to multiple cadherins. A431 (human cervical carcinoma), HUAEC, and C2C12 (mouse myocyte) cells express E- and P-cadherin, VE-cadherin, and N-cadherin, respectively. Each cell line was infected with either human- or murine-specific p120 siRNA retrovirus to generate polyclonal knockdown cell lines, and levels of p120 or E-, P-, VE-, and N-cadherins were assayed by Western blotting of whole-cell lysates. Tubulin levels were used as a loading control. p120 knockdown reduced expression of all these cadherins, indicating that its function is common to most (if not all) p120-associated cadherins. Note that the effects of the h and m siRNAs used for knockdown and control in the human cell lines are reversed in the murine cell line C2C12.