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. 2003 Dec 22;163(6):1197–1204. doi: 10.1083/jcb.200309088

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Copyright © 2003, The Rockefeller University Press

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Figure 5. — A model for coupling oskar mRNA localization and translational activation via Cup. (A) During stages 1–7, Cup is required to recruit plus end–directed transport factors, such as Btz. (B) During stages 8 and 9, the oskar RNP rearranges so that Btz can recruit kinesin. (C) During stages 9 and 10, oskar mRNA localizes to the posterior pole and is anchored there. This anchoring event or a posterior localized signal acts on Cup to cause partial disassembly of the complex and breaks the interaction between Cup and eIF4E allowing translation. Asterisks (*) mark interactions that may not be direct.