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. 2003 Dec 22;163(6):1213–1218. doi: 10.1083/jcb.200309147

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Copyright © 2003, The Rockefeller University Press

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Figure 1. — Binding analysis of the different paranodal junction components. (A) Schematic presentation of the Fc-fusion proteins used. (B) Immunoblot using an anti-Fc antibody showing the expression of the various Fc-fusion proteins in cell supernatants. Molecular mass markers are shown in kilodaltons on the right. βC-Fc contains the carbonic anhydrase domain of RPTPβ fused to human Fc. (C) NF155 directly binds contactin, but not Caspr. Binding was performed between the indicated Fc-fusion proteins (labeled on top of each panel) and COS-7 cells expressing either contactin or NF155, as indicated on the left. Cell surface expression of NF155 or contactin in the transfected cells, as determined by antibody staining to these proteins using nonpermeabilized cells is shown in the insets of each panel. All NF155 expressing cells bound contactin-Fc and NF155-Fc, whereas all contactin expressing cells bound NF155-Fc or βC-Fc.