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. 2003 Mar 17;160(6):833–843. doi: 10.1083/jcb.200211116

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Copyright © 2003, The Rockefeller University Press

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Figure 2. — Suppression of dicentric chromosome breakage in kinetochore mutants. (A–G) Colony morphology upon dicentric chromosome activation. Wild-type (A), ndc10-2 (B), mcm21Δ (C), iml3Δ (D), mcm16Δ (E), and ctf19Δ (F) cells are uniform in size and shape on galactose (monocentric for chromosome III) and heterogeneous in size and shape on glucose (dicentric for chromosome III). In contrast, chl4Δ cells (G) appear homogenous on both galactose and glucose. (H) Physical analysis of DNA repair. DNA recovered from RAD52 dicentric chromosome–containing cells after induction on glucose, lanes 1 and 2 (3 and 6 h on glucose) show a rearrangement product of 925 bp. DNA recovered from chl4Δ dicentric chromosome–containing cells, lanes 3–5 (3, 6, 9 h on glucose) do not show diagnostic rearrangement. chl4Δ dicentric chromosome–containing cells transformed with CHL4 on a CEN plasmid show rearrangement upon transfer to glucose, lanes 6–8 (3, 6, and 9 h in glucose media).