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. 2003 Mar 17;160(6):919–928. doi: 10.1083/jcb.200211012

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Copyright © 2003, The Rockefeller University Press

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Figure 2. — PKA phosphorylation of Ser²⁸⁴³ activates RyR1 channels. (A) Representative single channel tracings of WT RyR1, (B) RyR1-S2843A, (C) PKA-phosphorylated WT RyR1, (D) RyR1-S2843D, and (E) RyR1-V2461I (this mutant RyR1 was previously shown to bind FKBP12.6 but not FKBP12; Gaburjakova et al., 2001). RyR1 single channel recordings in planar lipid bilayers show activity of the channels at 150 nM [Ca²⁺]_cis with 1 mM ATP. Recordings were at 0 mV, closed state of the channels are indicated as C, and openings are upwards. All point amplitude histograms are shown. P_o and mean closed (Tc) and open (To) dwell times are shown above each channel tracing.