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. 2003 Mar 17;160(6):919–928. doi: 10.1083/jcb.200211012

Table I. PKA phosphorylation activates RyR1.

	Nonphosphorylated			PKA phosphorylated
	Open probability	Open time	Closed time	Open probability	Open time	Closed time
		ms	ms		ms	ms
RyR1 (n = 21)	0.34 ± 0.1^a	22.1 ± 2.4^a	36.7 ± 3.4^a	0.72 ± 0.1^a	1.6 ± 0.6^a	1.4 ± 0.5^a
RyR1-S2843A (n = 11)	0.29 ± 0.1	25.1 ± 2.1	34.4 ± 2.4	ND	ND	ND
RyR1-S2843D (n = 14)	0.81 ± 0.3^b	1.1 ± 0.3^b	1.9 ± 0.8^b	ND	ND	ND

^a

P < 0.001 for nonphosphorylated versus PKA phosphorylated.

^b

P < 0.001 for RyR1-S2843D versus nonphosphorylated WT.