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. 2002 Aug 5;158(3):395–399. doi: 10.1083/jcb.200205044

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Copyright © 2002, The Rockefeller University Press

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Figure 2. — Alterations of the cap binding protein complex eIF4F in infected cells. (Top) Cleavage of eIF4G by picornaviral proteases. (Middle) Sequestration of eIF4E by 4E binding proteins (4E-BP) due to dephosphorylation of 4E-BPs in picornavirus-infected cells. (Bottom) Eviction of PABP by viral NSP3 from the cap binding protein complex eIF4F in rotavirus- infected cells. Interactions of eukaryotic initiation factors eIF4G (4G), eIF4A (4A), eIF4E (4E), and eIF3 (3) are indicated.