Table 5.
Effect of Compounds on Trypsin Activity
| % Activity Remaining | ||
|---|---|---|
| Compound | IC50a | 200 μM |
| DMSO | 100.0 ± 8.7 | 100.0 ± 8.5 |
| TLCK | ND | 41.5 ± 0.4 |
| 1 | 94.2 ± 2.4 | 94.5 ± 1.3 |
| 2 | 118.5 ± 2.2 | 123.6 ± 8.0 |
| 3 | 73.5 ± 3.3 | 3.0 ± 1.4 |
| 4 | 89.6 ± 3.1 | 24.9 ± 0.9 |
| 5 | 76.9 ± 2.3 | 40.8 ± 4.3 |
| 6 | 103.4 ± 1.0 | 56.5 ± 1.6 |
| 7 | 103.3 ± 1.5 | 46.8 ± 2.5 |
| 8 | 99.3 ± 2.1 | 14.4 ± 2.2 |
| 9 | 101.1 ± 3.9 | 38.3 ± 0.9 |
ND, not determined.
As reported in Table 3 for Sc Rce1p. Values are derived from 4 independent measurements.