Table 1.
Immunogenicity of YF17D/Esa/5.1glic for BALB/c mice.
| Immunogen | Animals (n) | PRNT50* | ELISA-EGFP*** | ||||
| % Sero-conversion | GMT ± SD | Titer Range** | % Sero-conversion | GMT ± SD | Titer Range | ||
| YF 17DD | 15 | 100 | 140 ± 80 | 45 – 308 | 0 | < 16 | < 16 |
| YF17D/Esa/5.1glic | 20 | 100 | 80 ± 47 | 37 – 211 | 80 | 158 ± 1,144 | 26 – 3,535 |
| 199 Earle's Medium | 15 | 0 | < 10 | < 10 | 0 | < 16 | < 16 |
* Reciprocal of the dilution yielding 50% plaque reduction.
** Differences in the titers of neutralizing antibodies virus in animals immunized with YF 17DD and YF17D/Esa/5.1glic were statistically significant (t test; P < 0.02).
***The titer of antibodies directed against EGFP was calculated based on standard curves of a monoclonal antibody specific to GFP and is expressed in ng/mL.