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. 2003 Sep 29;162(7):1281–1292. doi: 10.1083/jcb.200304018

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Copyright © 2003, The Rockefeller University Press

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Figure 7. — Inhibition of ROCK enhances HGF-induced cell protrusions and attenuates the inhibitory effect of ephrin-A1. (A) Y27632 significantly attenuates ephrin-A1–induced inhibition of branching morphogenesis. MDCK branching morphogenesis assay was performed in the absence or presence of 10 μM Y27632. Cell images were taken 24 h later. Bar, 40 μm. (B) Quantitation of branching morphogenesis results in A. Values represent means from six randomly selected fields ± SD. (C) Y27632 inhibits ephrin-A1–induced collapse of preexisting membrane processes. Cell protrusions were induced in collagen gel by HGF in the presence of Y27632 for 24 h. Ephrin-A1–Fc was then added to the growth medium containing fresh HGF and Y27632. Branching morphogenesis response was recorded. Values represent means from six randomly selected fields ± SD.

Figure 7. — Inhibition of ROCK enhances HGF-induced cell protrusions and attenuates the inhibitory effect of ephrin-A1. (A) Y27632 significantly attenuates ephrin-A1–induced inhibition of branching morphogenesis. MDCK branching morphogenesis assay was performed in the absence or presence of 10 μM Y27632. Cell images were taken 24 h later. Bar, 40 μm. (B) Quantitation of branching morphogenesis results in A. Values represent means from six randomly selected fields ± SD. (C) Y27632 inhibits ephrin-A1–induced collapse of preexisting membrane processes. Cell protrusions were induced in collagen gel by HGF in the presence of Y27632 for 24 h. Ephrin-A1–Fc was then added to the growth medium containing fresh HGF and Y27632. Branching morphogenesis response was recorded. Values represent means from six randomly selected fields ± SD.