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. 2002 Dec 23;159(6):931–938. doi: 10.1083/jcb.200209124

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Copyright © 2002, The Rockefeller University Press

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Figure 2. — Apoptotic Bax clusters colocalize with sites of mitochondrial fragmentation. HeLa (A and B) and Cos-7 (C) cells were cotransfected with CFP-Bax and mito-YFP. At 12 h after transfection cells were treated with 1 μM STS and analyzed by confocal microscopy over time. Fragmentation and vesiculation of mitochondria began at the same time (between 75 and 80 min in A) that Bax (red) coalesced at mitochondrial scission sites (arrowheads). Fragmented mitochondria often remained connected by Bax-containing structures (A and B). Complete separation of fragmented mitochondria was also detected (C).