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Frequency of 6-TG resistance
| Cell line | No radiation | radiation |
|---|---|---|
| Msh2+/+ | ND (<2.7 × 10−6) | ND (<3.6 × 10−7) |
| Msh2+/− | ND (<1.7 × 10−6) | 1.5 × 10−6 (±0.7 × 10−6) |
| Msh2−/− | 5 × 10−4 (±0.7 × 10−4) | 2 × 10−3 (±0.4 × 10−3) |
Prevalence of 6-TG-resistant clones in ES cell cultures before and after protracted low level radiation exposure was assessed as described in Materials and Methods. ND, no 6-TG-resistant colonies detected.
